Assay Detail
Binding
CHEMBL652723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Quinazolinones 2: QSAR and in vivo characterization of AT1 selective AII antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.09 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25585 | — | — | 1 | 9.12 |
| CHEMBL25315 | — | — | 1 | 9.08 |
| CHEMBL25056 | — | — | 1 | 9.00 |
| CHEMBL287184 | — | — | 1 | 9.00 |
| CHEMBL24724 | — | — | 1 | 8.89 |
| CHEMBL24053 | — | — | 1 | 8.70 |
| CHEMBL281846 | — | — | 1 | 8.70 |
| CHEMBL26548 | — | — | 1 | 8.52 |
| CHEMBL24861 | — | — | 1 | 8.47 |
| CHEMBL422756 | — | — | 1 | 8.40 |
| CHEMBL23994 | — | — | 1 | 8.40 |
| CHEMBL282236 | — | — | 1 | 8.37 |
| CHEMBL25000 | — | — | 1 | 8.30 |
| CHEMBL24240 | — | — | 1 | 8.30 |
| CHEMBL24661 | — | — | 1 | 8.30 |
| CHEMBL279515 | — | — | 1 | 8.22 |
| CHEMBL280526 | — | — | 1 | 8.19 |
| CHEMBL282746 | — | — | 1 | 8.15 |
| CHEMBL26217 | — | — | 1 | 8.10 |
| CHEMBL277182 | — | — | 1 | 8.05 |
| CHEMBL24688 | — | — | 1 | 7.89 |
| CHEMBL284764 | — | — | 1 | 7.70 |
| CHEMBL25075 | — | — | 1 | 7.58 |
| CHEMBL26514 | — | — | 1 | 7.57 |
| CHEMBL24488 | — | — | 1 | 7.55 |
| CHEMBL422932 | — | — | 1 | 7.54 |
| CHEMBL284455 | — | — | 1 | 7.48 |
| CHEMBL24111 | — | — | 1 | 7.30 |
| CHEMBL287253 | — | — | 1 | 7.04 |
| CHEMBL25767 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25585 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL25315 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL25056 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL287184 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL24724 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL24053 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL281846 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL26548 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL24861 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL422756 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL23994 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL282236 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL25000 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL24240 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL24661 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL279515 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL280526 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL282746 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL26217 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL277182 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL24688 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL284764 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL25075 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL26514 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL24488 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL422932 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL284455 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL24111 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL287253 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL25767 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL284469 | — | IC50 | = | 940.0 | nM | 6.03 |