Assay Detail
Binding
CHEMBL652725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.59 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367569 | — | — | 1 | 9.52 |
| CHEMBL173643 | — | — | 1 | 9.40 |
| CHEMBL176473 | — | — | 1 | 9.05 |
| CHEMBL168771 | — | — | 1 | 9.00 |
| CHEMBL408798 | — | — | 1 | 8.89 |
| CHEMBL302102 | — | — | 1 | 8.82 |
| CHEMBL408799 | — | — | 1 | 8.82 |
| CHEMBL368149 | — | — | 1 | 8.41 |
| CHEMBL173455 | — | — | 1 | 8.06 |
| CHEMBL367095 | — | — | 1 | 7.96 |
| CHEMBL172376 | — | — | 1 | 7.64 |
| CHEMBL174080 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367569 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL173643 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL176473 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL168771 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL408798 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL302102 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL408799 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL368149 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL173455 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL367095 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL172376 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL174080 | — | IC50 | = | 30.0 | nM | 7.52 |