Assay Detail
Binding
CHEMBL652743
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Ability to displace [3H]prazosin from alpha-1 adrenergic receptor in rat brain homogenates in vitro
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.84 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | -1.0 | 1 | 7.11 |
| CHEMBL545646 | — | — | 1 | 6.83 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL545646 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 261.0 | nM | 6.58 |