Assay Detail
Binding
CHEMBL652803
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In vitro binding affinity towards alpha-1A adrenergic receptor of bovine clone in radioligand binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.42 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317912 | — | — | 1 | 6.94 |
| CHEMBL323402 | — | — | 1 | 6.86 |
| CHEMBL109827 | — | — | 1 | 6.83 |
| CHEMBL112814 | — | — | 1 | 6.16 |
| CHEMBL326862 | — | — | 1 | 6.01 |
| CHEMBL327116 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317912 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL323402 | — | Ki | = | 138.04 | nM | 6.86 |
| CHEMBL109827 | — | Ki | = | 147.91 | nM | 6.83 |
| CHEMBL112814 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL326862 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL327116 | — | Ki | = | 2041.74 | nM | 5.69 |