Assay Detail
Binding
CHEMBL652868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 9.27 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265797 | — | — | 1 | 10.28 |
| CHEMBL316300 | — | — | 1 | 9.96 |
| CHEMBL329679 | — | — | 1 | 9.82 |
| CHEMBL96075 | — | — | 1 | 9.80 |
| CHEMBL93907 | — | — | 1 | 9.77 |
| CHEMBL319730 | — | — | 1 | 9.60 |
| CHEMBL276674 | — | — | 1 | 9.54 |
| CHEMBL92533 | — | — | 1 | 9.51 |
| CHEMBL292150 | — | — | 1 | 9.35 |
| CHEMBL313868 | — | — | 1 | 9.21 |
| CHEMBL323506 | — | — | 1 | 9.08 |
| CHEMBL321531 | — | — | 1 | 9.05 |
| CHEMBL94793 | — | — | 1 | 9.00 |
| CHEMBL316299 | — | — | 1 | 8.89 |
| CHEMBL321313 | — | — | 1 | 8.85 |
| CHEMBL302102 | — | — | 1 | 8.77 |
| CHEMBL96314 | — | — | 1 | 8.41 |
| CHEMBL96554 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265797 | — | IC50 | = | 0.052 | nM | 10.28 |
| CHEMBL316300 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL329679 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL96075 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL93907 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL319730 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL276674 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL92533 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL292150 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL313868 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL323506 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL321531 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL94793 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL316299 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL321313 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL302102 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL96314 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL96554 | — | IC50 | = | 10.0 | nM | 8.00 |