Assay Detail
Binding
CHEMBL653024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.28 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104174 | — | — | 1 | 8.40 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 8.10 |
| CHEMBL106237 | — | — | 1 | 7.93 |
| CHEMBL106438 | — | — | 1 | 7.92 |
| CHEMBL321069 | — | — | 1 | 7.92 |
| CHEMBL321916 | — | — | 1 | 7.87 |
| CHEMBL107785 | — | — | 1 | 7.84 |
| CHEMBL104993 | — | — | 1 | 7.73 |
| CHEMBL317897 | — | — | 1 | 7.72 |
| CHEMBL432608 | ALPDEM | — | 1 | 7.70 |
| CHEMBL107008 | — | — | 1 | 7.64 |
| CHEMBL323180 | — | — | 1 | 7.47 |
| CHEMBL104343 | — | — | 1 | 7.46 |
| CHEMBL104686 | — | — | 1 | 7.43 |
| CHEMBL450283 | — | — | 1 | 7.26 |
| CHEMBL320366 | — | — | 1 | 7.10 |
| CHEMBL317473 | — | — | 1 | 6.54 |
| CHEMBL104401 | — | — | 1 | 6.37 |
| CHEMBL316555 | — | — | 1 | 5.69 |
| CHEMBL104864 | — | — | 1 | 5.49 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 5.33 |
| CHEMBL320918 | — | — | 1 | - |
| CHEMBL104007 | — | — | 1 | - |
| CHEMBL106775 | — | — | 1 | - |
| CHEMBL107905 | — | — | 1 | - |
| CHEMBL106717 | — | — | 1 | - |
| CHEMBL106780 | — | — | 1 | - |
| CHEMBL321345 | — | — | 1 | - |
| CHEMBL322570 | — | — | 1 | - |
| CHEMBL104724 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104174 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL54349 | ALPIDEM | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL106237 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL106438 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL321069 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL321916 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL107785 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL104993 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL317897 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL432608 | ALPDEM | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL107008 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL323180 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL104343 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL104686 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL450283 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL320366 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL317473 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL104401 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL316555 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL104864 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL911 | ZOLPIDEM | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL430693 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL319873 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL106691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL415506 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL108109 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL322388 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL107295 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL322725 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104537 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL321202 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420468 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL108259 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL104724 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL322570 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL321345 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL106780 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL106717 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL107905 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL106775 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL104007 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL320918 | — | IC50 | > | 100000.0 | nM | - |