Compound Detail
CHEMBL104174
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Basic Information
| ChEMBL ID | CHEMBL104174 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BEHDVQNYCZMGCM-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
369.9
MW (Da)
4.85
ALogP
3
HBA
0
HBD
37.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
EC50 1 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Translocator protein CHEMBL4552 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| GABA-A receptor; anion channel CHEMBL1907607 | IC50 | 7.07 | 7.07 | 86.0 | 1 |
| GABA A receptor alpha-2/beta-2/gamma-2 CHEMBL2111413 | EC50 | 6.89 | 6.89 | 130.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Translocator protein | IC50 | = | 4.0 | nM | 8.4 | Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor | 9301675 |
| GABA-A receptor; anion channel | IC50 | = | 86.0 | nM | 7.07 | Displacement of [3H]flunitrazepam from rat brain GABA-A Benzodiazepine receptor | 9301675 |
| GABA A receptor alpha-2/beta-2/gamma-2 | EC50 | = | 130.0 | nM | 6.89 | Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alp... | 9301675 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9301675 | 10.1021/jm970112+ | GABA A receptor alpha-2/beta-2/gamma-2 | 2 |
| 9301675 | 10.1021/jm970112+ | GABA-A receptor; anion channel | 1 |
| 9301675 | 10.1021/jm970112+ | Translocator protein | 1 |
Data from ChEMBL 36 via Core Engine