Assay Detail
Functional
CHEMBL653376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atria
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 5.03 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40626 | — | — | 1 | 6.02 |
| CHEMBL289858 | — | — | 1 | 5.90 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 5.78 |
| CHEMBL287766 | — | — | 1 | 5.33 |
| CHEMBL289868 | — | — | 1 | 5.08 |
| CHEMBL288140 | — | — | 1 | 4.84 |
| CHEMBL41839 | — | — | 1 | 4.77 |
| CHEMBL41378 | — | — | 1 | 4.70 |
| CHEMBL40783 | — | — | 1 | 4.68 |
| CHEMBL431713 | — | — | 1 | 4.61 |
| CHEMBL289093 | BUTOXAMINE | 2.0 | 1 | 4.35 |
| CHEMBL40971 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40626 | — | Kd | = | 954.99 | nM | 6.02 |
| CHEMBL289858 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 1659.59 | nM | 5.78 |
| CHEMBL287766 | — | Kd | = | 4677.35 | nM | 5.33 |
| CHEMBL289868 | — | Kd | = | 8317.64 | nM | 5.08 |
| CHEMBL288140 | — | Kd | = | 14454.4 | nM | 4.84 |
| CHEMBL41839 | — | Kd | = | 16982.44 | nM | 4.77 |
| CHEMBL41378 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL40783 | — | Kd | = | 20892.96 | nM | 4.68 |
| CHEMBL431713 | — | Kd | = | 24547.09 | nM | 4.61 |
| CHEMBL289093 | BUTOXAMINE | Kd | = | 44668.36 | nM | 4.35 |
| CHEMBL40971 | — | Kd | = | 53703.18 | nM | 4.27 |