Assay Detail
Binding
CHEMBL653377
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Beta-1 adrenergic receptor activation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and beta-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 24 | 7.58 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304344 | — | — | 1 | 9.82 |
| CHEMBL7154 | — | — | 1 | 8.77 |
| CHEMBL69635 | — | — | 1 | 8.75 |
| CHEMBL67096 | TOLIPROLOL | 2.0 | 1 | 8.75 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.60 |
| CHEMBL67151 | — | — | 1 | 8.40 |
| CHEMBL302339 | — | — | 1 | 8.06 |
| CHEMBL68419 | — | — | 1 | 7.71 |
| CHEMBL66384 | — | — | 1 | 7.39 |
| CHEMBL302935 | — | — | 1 | 7.31 |
| CHEMBL63582 | — | — | 1 | 7.25 |
| CHEMBL67631 | — | — | 1 | 7.24 |
| CHEMBL66702 | — | — | 1 | 7.09 |
| CHEMBL419994 | — | — | 1 | 7.02 |
| CHEMBL66662 | — | — | 1 | 7.00 |
| CHEMBL66724 | — | — | 1 | 6.80 |
| CHEMBL66449 | — | — | 1 | 6.60 |
| CHEMBL66324 | — | — | 1 | 6.56 |
| CHEMBL302605 | — | — | 1 | 6.42 |
| CHEMBL66331 | — | — | 1 | 5.98 |
| CHEMBL68996 | — | — | 1 | - |
| CHEMBL68945 | — | — | 1 | - |
| CHEMBL67331 | — | — | 1 | - |
| CHEMBL304725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304344 | — | Kd | = | 0.1514 | nM | 9.82 |
| CHEMBL7154 | — | Kd | = | 1.698 | nM | 8.77 |
| CHEMBL69635 | — | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL67096 | TOLIPROLOL | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL67151 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL302339 | — | Kd | = | 8.71 | nM | 8.06 |
| CHEMBL68419 | — | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL66384 | — | Kd | = | 40.74 | nM | 7.39 |
| CHEMBL302935 | — | Kd | = | 48.98 | nM | 7.31 |
| CHEMBL63582 | — | Kd | = | 56.23 | nM | 7.25 |
| CHEMBL67631 | — | Kd | = | 57.54 | nM | 7.24 |
| CHEMBL66702 | — | Kd | = | 81.28 | nM | 7.09 |
| CHEMBL419994 | — | Kd | = | 95.5 | nM | 7.02 |
| CHEMBL66662 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL66724 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL66449 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL66324 | — | Kd | = | 275.42 | nM | 6.56 |
| CHEMBL302605 | — | Kd | = | 380.19 | nM | 6.42 |
| CHEMBL66331 | — | Kd | = | 1047.13 | nM | 5.98 |
| CHEMBL68996 | — | Kd | > | 257.04 | nM | - |
| CHEMBL68945 | — | Kd | > | 7.943 | nM | - |
| CHEMBL67331 | — | Kd | > | 102.33 | nM | - |
| CHEMBL304725 | — | Kd | > | 70.79 | nM | - |