Assay Detail
Functional
CHEMBL653725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for smooth muscle calcium channel antagonist activity
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The design of (-)-(S)-2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate: a cardioselective positive inotropic derivative of Bay K 8644.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.57 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86350 | — | — | 1 | 7.10 |
| CHEMBL283013 | — | — | 1 | 4.80 |
| CHEMBL439953 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86350 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL283013 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL439953 | — | IC50 | = | 16000.0 | nM | 4.80 |