Assay Detail
Functional
CHEMBL653748
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Antitumor activity was evaluated against CEM cell line
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.19 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 4.61 |
| CHEMBL284668 | — | — | 1 | 4.28 |
| CHEMBL26037 | — | — | 1 | 4.08 |
| CHEMBL26949 | — | — | 1 | 4.06 |
| CHEMBL26364 | — | — | 1 | 4.05 |
| CHEMBL280582 | — | — | 1 | 4.04 |
| CHEMBL287512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090 | VIDARABINE | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL284668 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL26037 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL26949 | — | IC50 | = | 86700.0 | nM | 4.06 |
| CHEMBL26364 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL280582 | — | IC50 | = | 90500.0 | nM | 4.04 |
| CHEMBL287512 | — | IC50 | > | 200000.0 | nM | - |