Assay Detail
Binding
CHEMBL654565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nitrendipine binding to calcium channel of rat brain membranes.
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Novel stereoselective calcium channel ligands of the diphenylalkylamine-type
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.88 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24813 | — | — | 2 | 7.03 |
| CHEMBL24072 | PRENYLAMINE | 4.0 | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24813 | — | Kd | = | 93.6 | nM | 7.03 |
| CHEMBL24813 | — | Kd | = | 115.0 | nM | 6.94 |
| CHEMBL24072 | PRENYLAMINE | Kd | = | 209.0 | nM | 6.68 |