Compound Detail
CHEMBL24813
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Basic Information
| ChEMBL ID | CHEMBL24813 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KDFLJSUYAYTTKJ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
490.1
MW (Da)
7.61
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.33
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated L-type calcium channel CHEMBL2095177 | Kd | 7.03 | 6.985 | 93.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated L-type calcium channel | Kd | = | 93.6 | nM | 7.03 | Inhibition of [3H]nitrendipine binding to calcium channel of rat brain membranes... | - |
| Voltage-gated L-type calcium channel | Kd | = | 115.0 | nM | 6.94 | Inhibition of [3H]nitrendipine binding to calcium channel of rat brain membranes... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80231-0 | Voltage-gated L-type calcium channel | 2 |
Data from ChEMBL 36 via Core Engine