Assay Detail
Functional
CHEMBL655647
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Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.02 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.51 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | — | 1 | 8.24 |
| CHEMBL171432 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | Kd | = | 3.09 | nM | 8.51 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | Kd | = | 5.754 | nM | 8.24 |
| CHEMBL171432 | — | Kd | = | 50.12 | nM | 7.30 |