Assay Detail
Functional
CHEMBL655650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig arteria
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.36 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148306 | (S)-METOPROLOL | — | 1 | 8.12 |
| CHEMBL13 | METOPROLOL | 4.0 | 1 | 7.83 |
| CHEMBL1741004 | (R)-METOPROLOL | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148306 | (S)-METOPROLOL | Kd | = | 7.586 | nM | 8.12 |
| CHEMBL13 | METOPROLOL | Kd | = | 14.79 | nM | 7.83 |
| CHEMBL1741004 | (R)-METOPROLOL | Kd | = | 741.31 | nM | 6.13 |