Assay Detail
Functional
CHEMBL655651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.76 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499 | TIMOLOL | 4.0 | 1 | 9.44 |
| CHEMBL1788270 | — | — | 1 | 7.88 |
| CHEMBL2110257 | — | — | 1 | 7.78 |
| CHEMBL1744069 | — | — | 1 | 7.57 |
| CHEMBL368457 | — | — | 1 | 7.47 |
| CHEMBL173976 | — | — | 1 | 7.46 |
| CHEMBL305153 | — | — | 1 | 7.43 |
| CHEMBL26917 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499 | TIMOLOL | Kd | = | 0.3631 | nM | 9.44 |
| CHEMBL1788270 | — | Kd | = | 13.18 | nM | 7.88 |
| CHEMBL2110257 | — | Kd | = | 16.6 | nM | 7.78 |
| CHEMBL1744069 | — | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL368457 | — | Kd | = | 33.88 | nM | 7.47 |
| CHEMBL173976 | — | Kd | = | 34.67 | nM | 7.46 |
| CHEMBL305153 | — | Kd | = | 37.15 | nM | 7.43 |
| CHEMBL26917 | — | Kd | = | 97.72 | nM | 7.01 |