Assay Detail
Functional
CHEMBL655820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to cause cAMP accumulation in CHO cells expressing human beta-2 AR expressed as the negative logarithm of the molar drug concentration
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.57 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154370 | — | — | 1 | 9.00 |
| CHEMBL345304 | — | — | 1 | 8.50 |
| CHEMBL153916 | — | — | 1 | 8.30 |
| CHEMBL154150 | — | — | 1 | 8.10 |
| CHEMBL348269 | — | — | 1 | 8.00 |
| CHEMBL155072 | — | — | 1 | 8.00 |
| CHEMBL157210 | — | — | 1 | 7.70 |
| CHEMBL347616 | — | — | 1 | 7.50 |
| CHEMBL154036 | — | — | 1 | 7.30 |
| CHEMBL152535 | — | — | 1 | 7.30 |
| CHEMBL154419 | — | — | 1 | 7.30 |
| CHEMBL348501 | — | — | 1 | 7.10 |
| CHEMBL153558 | — | — | 1 | 6.40 |
| CHEMBL155092 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154370 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL345304 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL153916 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL154150 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL348269 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL155072 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL157210 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL347616 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL154036 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL152535 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL154419 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL348501 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL153558 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL155092 | — | EC50 | = | 3162.28 | nM | 5.50 |