Compound Detail
CHEMBL154036
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Basic Information
| ChEMBL ID | CHEMBL154036 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XLHISXVBDXEKEW-ACJLOTCBSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
362.9
MW (Da)
3.09
ALogP
4
HBA
4
HBD
81.6
PSA (Ų)
0.55
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL210 | EC50 | 7.3 | 7.3 | 50.1 | 1 |
| Beta-3 adrenergic receptor CHEMBL246 | EC50 | 6.5 | 6.5 | 316.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | EC50 | = | 50.12 | nM | 7.3 | Ability to cause cAMP accumulation in CHO cells expressing human beta-2 AR expre... | 11806709 |
| Beta-3 adrenergic receptor | EC50 | = | 316.23 | nM | 6.5 | Ability to cause cAMP accumulation in CHO cells expressing human beta-3 AR expre... | 11806709 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11806709 | 10.1021/jm0101500 | Beta-3 adrenergic receptor | 2 |
| 11806709 | 10.1021/jm0101500 | Beta-2 adrenergic receptor | 2 |
| 11806709 | 10.1021/jm0101500 | Beta-1 adrenergic receptor | 2 |
| 11806709 | 10.1021/jm0101500 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine