Assay Detail
Binding
CHEMBL656250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
CCKB selective receptor ligands: novel 1,3,5-trisubstituted benzazepin-2-ones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.73 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30919 | — | — | 1 | 8.16 |
| CHEMBL9387 | L-365260 | — | 1 | 8.07 |
| CHEMBL34335 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30919 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL9387 | L-365260 | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL34335 | — | IC50 | = | 110.0 | nM | 6.96 |