Assay Detail
Functional
CHEMBL656867
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Chronotropic effects were assayed in vitro in the isolated right artium of the cat.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Felis catus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 4.36 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443039 | — | — | 1 | 5.00 |
| CHEMBL166386 | — | — | 1 | 4.77 |
| CHEMBL355293 | — | — | 1 | 4.15 |
| CHEMBL168342 | — | — | 1 | 4.10 |
| CHEMBL355351 | — | — | 1 | 4.07 |
| CHEMBL169113 | — | — | 1 | 4.06 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | - |
| CHEMBL352493 | — | — | 1 | - |
| CHEMBL354520 | — | — | 1 | - |
| CHEMBL167101 | — | — | 1 | - |
| CHEMBL354138 | — | — | 1 | - |
| CHEMBL168623 | — | — | 1 | - |
| CHEMBL422375 | — | — | 1 | - |
| CHEMBL166414 | — | — | 1 | - |
| CHEMBL167726 | — | — | 1 | - |
| CHEMBL17125 | PELRINONE | 2.0 | 1 | - |
| CHEMBL168456 | — | — | 1 | - |
| CHEMBL262775 | — | — | 1 | - |
| CHEMBL165705 | — | — | 1 | - |
| CHEMBL169024 | — | — | 1 | - |
| CHEMBL249856 | ENOXIMONE | 3.0 | 1 | - |
| CHEMBL166525 | — | — | 1 | - |
| CHEMBL355520 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443039 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL166386 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL355293 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL168342 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL355351 | — | EC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL169113 | — | EC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL189 | MILRINONE | EC50 | ~ | 300000.0 | nM | - |
| CHEMBL352493 | — | EC50 | = | 300000.0 | nM | - |
| CHEMBL354520 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL167101 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL354138 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL168623 | — | EC50 | = | 420000.0 | nM | - |
| CHEMBL422375 | — | EC50 | ~ | 1000000.0 | nM | - |
| CHEMBL166414 | — | EC50 | = | 230000.0 | nM | - |
| CHEMBL167726 | — | EC50 | = | 250000.0 | nM | - |
| CHEMBL17125 | PELRINONE | EC50 | = | 212000.0 | nM | - |
| CHEMBL168456 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL262775 | — | EC50 | = | 180000.0 | nM | - |
| CHEMBL165705 | — | EC50 | = | 380000.0 | nM | - |
| CHEMBL169024 | — | EC50 | = | 300000.0 | nM | - |
| CHEMBL249856 | ENOXIMONE | EC50 | = | 200000.0 | nM | - |
| CHEMBL166525 | — | EC50 | = | 110000.0 | nM | - |
| CHEMBL355520 | — | EC50 | = | 396000.0 | nM | - |