Assay Detail
Functional
CHEMBL657453
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Cytotoxic activity against human lymphoblast tumor cell line CPT-K5 after 4 days of treatment
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.90 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 6.55 |
| CHEMBL72772 | — | — | 1 | 6.48 |
| CHEMBL72223 | — | — | 1 | 6.42 |
| CHEMBL71086 | — | — | 1 | 6.22 |
| CHEMBL70790 | — | — | 1 | 6.05 |
| CHEMBL415117 | — | — | 1 | 6.02 |
| CHEMBL309352 | — | — | 1 | 6.00 |
| CHEMBL309355 | — | — | 1 | 5.55 |
| CHEMBL72726 | — | — | 1 | 5.50 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 4.21 |
| CHEMBL424421 | — | — | 1 | - |
| CHEMBL73950 | — | — | 1 | - |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | - |
| CHEMBL306476 | — | — | 1 | - |
| CHEMBL304505 | — | — | 1 | - |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL72772 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL72223 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL71086 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL70790 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL415117 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL309352 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL309355 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL72726 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL424421 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL73950 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL481 | IRINOTECAN | IC50 | > | 100000.0 | nM | - |
| CHEMBL306476 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL304505 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL84 | TOPOTECAN | IC50 | > | 50000.0 | nM | - |