Assay Detail
Functional
CHEMBL657550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro anti-HIV screen using HIV-1 infected CD4 lymphocytes (CEM cell line), determines cytotoxicity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.14 | 4.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142658 | — | — | 1 | 4.14 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL3142666 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL3142668 | — | — | 1 | - |
| CHEMBL3142665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142658 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 390000.0 | nM | - |
| CHEMBL3142666 | — | IC50 | > | 327000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 440000.0 | nM | - |
| CHEMBL3142668 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL3142665 | — | IC50 | = | 113000.0 | nM | - |