Assay Detail
Binding
CHEMBL657832
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Inhibitory activity against human carbonic anhydrase I.
32
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 5.71 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL154865 | — | — | 1 | 7.00 |
| CHEMBL152907 | SULFAMIC ACID TETRADECYL ESTER | — | 1 | 6.82 |
| CHEMBL153027 | SULFAMIC ACID DODECYL ESTER | — | 1 | 6.57 |
| CHEMBL345776 | — | — | 1 | 6.40 |
| CHEMBL436261 | SULFAMIC ACID PHENETHYL ESTER | — | 1 | 6.39 |
| CHEMBL422864 | — | — | 1 | 6.39 |
| CHEMBL356681 | SULFAMIC ACID UNDECYL ESTER | — | 1 | 6.37 |
| CHEMBL153094 | DECYL SULFAMATE | — | 2 | 6.28 |
| CHEMBL358643 | SULFAMIC ACID PENTYL ESTER | — | 1 | 6.15 |
| CHEMBL440912 | SULFAMIC ACID BENZYL ESTER | — | 1 | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL150652 | SULFAMIC ACID BUTYL ESTER | — | 1 | 5.51 |
| CHEMBL357533 | — | — | 1 | 5.45 |
| CHEMBL348471 | SULFAMIC ACID PROPYL ESTER | — | 1 | 5.43 |
| CHEMBL345493 | — | — | 1 | 5.33 |
| CHEMBL153068 | — | — | 1 | 5.11 |
| CHEMBL152994 | — | — | 1 | 4.42 |
| CHEMBL149514 | SULFAMIC ACID ETHYL ESTER | — | 1 | 4.42 |
| CHEMBL150650 | SULFAMIC ACID METHYL ESTER | — | 1 | 4.40 |
| CHEMBL152962 | SULFAMIC ACID HEXADECYL ESTER | — | 1 | 4.24 |
| CHEMBL346866 | SULFAMIC ACID CYCLOHEXYL ESTER | — | 1 | 4.23 |
| CHEMBL450930 | SULFAMIC ACID OCTADECYL ESTER | — | 1 | 4.19 |
| CHEMBL346884 | — | — | 1 | - |
| CHEMBL150300 | SULFAMIC ACID CYCLOPENTYL ESTER | — | 1 | - |
| CHEMBL357535 | — | — | 1 | - |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | - |
| CHEMBL357339 | — | — | 1 | - |
| CHEMBL153718 | SULFAMIC ACID ISOPROPYL ESTER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL154865 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL152907 | SULFAMIC ACID TETRADECYL ESTER | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL153027 | SULFAMIC ACID DODECYL ESTER | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL345776 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL436261 | SULFAMIC ACID PHENETHYL ESTER | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL422864 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL356681 | SULFAMIC ACID UNDECYL ESTER | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL358643 | SULFAMIC ACID PENTYL ESTER | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL440912 | SULFAMIC ACID BENZYL ESTER | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL150652 | SULFAMIC ACID BUTYL ESTER | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL357533 | — | Ki | = | 3540.0 | nM | 5.45 |
| CHEMBL348471 | SULFAMIC ACID PROPYL ESTER | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL345493 | — | Ki | = | 4620.0 | nM | 5.33 |
| CHEMBL153068 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL152994 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL149514 | SULFAMIC ACID ETHYL ESTER | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL150650 | SULFAMIC ACID METHYL ESTER | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL152962 | SULFAMIC ACID HEXADECYL ESTER | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL346866 | SULFAMIC ACID CYCLOHEXYL ESTER | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL450930 | SULFAMIC ACID OCTADECYL ESTER | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL346884 | — | Ki | = | 800000.0 | nM | - |
| CHEMBL150300 | SULFAMIC ACID CYCLOPENTYL ESTER | Ki | > | 1000000.0 | nM | - |
| CHEMBL153094 | DECYL SULFAMATE | Ki | > | 1000000.0 | nM | - |
| CHEMBL357535 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 400000.0 | nM | - |
| CHEMBL357339 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL153718 | SULFAMIC ACID ISOPROPYL ESTER | Ki | = | 690000.0 | nM | - |
| CHEMBL152967 | — | Ki | = | 990000.0 | nM | - |