Assay Detail
Binding
CHEMBL658337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human Coagulation factor X
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.71 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20918 | — | — | 1 | 9.15 |
| CHEMBL279486 | — | — | 1 | 9.15 |
| CHEMBL21250 | — | — | 1 | 9.15 |
| CHEMBL20438 | — | — | 1 | 9.05 |
| CHEMBL20391 | — | — | 1 | 9.00 |
| CHEMBL281838 | — | — | 1 | 8.92 |
| CHEMBL20488 | — | — | 1 | 8.55 |
| CHEMBL21140 | — | — | 1 | 8.41 |
| CHEMBL280925 | — | — | 1 | 8.41 |
| CHEMBL21179 | — | — | 1 | 8.39 |
| CHEMBL20897 | — | — | 1 | 8.28 |
| CHEMBL21052 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20918 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL279486 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL21250 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL20438 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL20391 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL281838 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL20488 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL21140 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL280925 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL21179 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL20897 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL21052 | — | Ki | = | 8.0 | nM | 8.10 |