Assay Detail
Binding
CHEMBL658338
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Binding affinity against human coagulation factor X
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.76 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94775 | — | — | 1 | 7.85 |
| CHEMBL328772 | — | — | 1 | 7.37 |
| CHEMBL48608 | — | — | 1 | 7.28 |
| CHEMBL96433 | — | — | 1 | 7.11 |
| CHEMBL316334 | — | — | 1 | 7.11 |
| CHEMBL330234 | — | — | 1 | 7.05 |
| CHEMBL91962 | — | — | 1 | 6.68 |
| CHEMBL52427 | — | — | 1 | 6.68 |
| CHEMBL330244 | — | — | 1 | 6.52 |
| CHEMBL92883 | — | — | 1 | 6.47 |
| CHEMBL95097 | — | — | 1 | 6.24 |
| CHEMBL96494 | — | — | 1 | 6.05 |
| CHEMBL92251 | — | — | 1 | 6.03 |
| CHEMBL327789 | — | — | 1 | 5.89 |
| CHEMBL327715 | — | — | 1 | 5.68 |
| CHEMBL284805 | — | — | 1 | 5.57 |
| CHEMBL93269 | — | — | 1 | 5.30 |
| CHEMBL94254 | — | — | 1 | 5.24 |
| CHEMBL92277 | — | — | 1 | 5.17 |
| CHEMBL318363 | — | — | 1 | 5.17 |
| CHEMBL92250 | — | — | 1 | 5.11 |
| CHEMBL96493 | — | — | 1 | 5.05 |
| CHEMBL92865 | — | — | 1 | 5.03 |
| CHEMBL319997 | — | — | 1 | 5.00 |
| CHEMBL92964 | — | — | 1 | 5.00 |
| CHEMBL433501 | — | — | 1 | 4.85 |
| CHEMBL433179 | — | — | 1 | 4.80 |
| CHEMBL94139 | — | — | 1 | 4.80 |
| CHEMBL318526 | — | — | 1 | 4.72 |
| CHEMBL330460 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94775 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL328772 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL48608 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL96433 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL316334 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL330234 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL91962 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL52427 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL330244 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL92883 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL95097 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL96494 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL92251 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL327789 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL327715 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL284805 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL93269 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL94254 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL92277 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL318363 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL92250 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL96493 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL92865 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL319997 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL92964 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL433501 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL433179 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL94139 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL318526 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL330460 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL96428 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL321510 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL96917 | — | Ki | = | 125000.0 | nM | - |