Compound Detail
CHEMBL433179
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Basic Information
| ChEMBL ID | CHEMBL433179 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VPEKNUPXKQVCLF-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
266.3
MW (Da)
2.53
ALogP
3
HBA
4
HBD
98.8
PSA (Ų)
0.42
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 5.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 5.12 | 5.12 | 7500.0 | 1 |
| Serine protease 1 CHEMBL209 | Ki | 5.05 | 5.05 | 9000.0 | 1 |
| Coagulation factor X CHEMBL244 | Ki | 4.8 | 4.8 | 16000.0 | 1 |
| Plasminogen CHEMBL1801 | Ki | 4.22 | 4.22 | 60000.0 | 1 |
| Prothrombin CHEMBL204 | Ki | 4.19 | 4.19 | 65000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | Ki | = | 7500.0 | nM | 5.12 | ComInhibition of Human Serine Protease Urokinase Plasminogen Activator (u-PA). | 11495587 |
| Serine protease 1 | Ki | = | 9000.0 | nM | 5.05 | Inhibition of Human Serine Protease Trypsin. | 11495587 |
| Coagulation factor X | Ki | = | 16000.0 | nM | 4.8 | Binding affinity against human coagulation factor X | 11495587 |
| Plasminogen | Ki | = | 60000.0 | nM | 4.22 | Inhibition of Human Serine Protease Plasmin. | 11495587 |
| Prothrombin | Ki | = | 65000.0 | nM | 4.19 | Inhibition of Human Serine Protease Thrombin. | 11495587 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11495587 | 10.1021/jm0100638 | Urokinase-type plasminogen activator | 1 |
| 11495587 | 10.1021/jm0100638 | Tissue-type plasminogen activator | 1 |
| 11495587 | 10.1021/jm0100638 | Coagulation factor X | 1 |
| 11495587 | 10.1021/jm0100638 | Prothrombin | 1 |
| 11495587 | 10.1021/jm0100638 | Plasminogen | 1 |
| 11495587 | 10.1021/jm0100638 | Serine protease 1 | 1 |
Data from ChEMBL 36 via Core Engine