Assay Detail
Functional
CHEMBL658539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.92 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.48 |
| CHEMBL97206 | — | — | 1 | 8.05 |
| CHEMBL266282 | AL-43 | — | 3 | 7.85 |
| CHEMBL138098 | — | — | 1 | 7.47 |
| CHEMBL337112 | — | — | 1 | 7.42 |
| CHEMBL336041 | — | — | 1 | 7.12 |
| CHEMBL141915 | — | — | 1 | 7.11 |
| CHEMBL141282 | — | — | 1 | 6.84 |
| CHEMBL137982 | — | — | 1 | 6.65 |
| CHEMBL141344 | — | — | 1 | 6.58 |
| CHEMBL138003 | — | — | 1 | 6.50 |
| CHEMBL137890 | — | — | 1 | 6.40 |
| CHEMBL140336 | — | — | 1 | 6.39 |
| CHEMBL138197 | — | — | 1 | 6.34 |
| CHEMBL141426 | — | — | 1 | 6.28 |
| CHEMBL141524 | — | — | 1 | 5.30 |
| CHEMBL138737 | — | — | 1 | - |
| CHEMBL138957 | — | — | 1 | - |
| CHEMBL141361 | — | — | 1 | - |
| CHEMBL141836 | — | — | 1 | - |
| CHEMBL138753 | — | — | 1 | - |
| CHEMBL140553 | — | — | 1 | - |
| CHEMBL342819 | — | — | 1 | - |
| CHEMBL343135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL97206 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL266282 | AL-43 | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL266282 | AL-43 | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL138098 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL337112 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL336041 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL141915 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL141282 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL137982 | — | EC50 | = | 223.0 | nM | 6.65 |
| CHEMBL141344 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL138003 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL137890 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL140336 | — | EC50 | = | 405.0 | nM | 6.39 |
| CHEMBL138197 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL266282 | AL-43 | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL141426 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL141524 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL138737 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL141361 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL138957 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL141836 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL138753 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL140553 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL342819 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL343135 | — | EC50 | > | 5000.0 | nM | - |