Compound Detail
CHEMBL336041
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Basic Information
| ChEMBL ID | CHEMBL336041 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DWGAKCJFXFNMID-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
349.5
MW (Da)
6.20
ALogP
3
HBA
1
HBD
30.5
PSA (Ų)
0.72
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.16
Ki 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 7.16 | 7.14 | 70.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Ki | = | 5.0 | nM | 8.3 | Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]dexameth... | 11728194 |
| Glucocorticoid receptor | EC50 | = | 70.0 | nM | 7.16 | Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc). | 11728194 |
| Glucocorticoid receptor | EC50 | = | 75.0 | nM | 7.12 | The effective concentration in CV-1 cells for glucocorticoid response element ac... | 11728194 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11728194 | 10.1021/jm010367u | Glucocorticoid receptor | 5 |
| 11728194 | 10.1021/jm010367u | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine