Assay Detail
Functional
CHEMBL694626
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Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.31 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.59 |
| CHEMBL97206 | — | — | 1 | 8.40 |
| CHEMBL266282 | AL-43 | — | 3 | 8.16 |
| CHEMBL141836 | — | — | 1 | 7.82 |
| CHEMBL337112 | — | — | 1 | 7.75 |
| CHEMBL141915 | — | — | 1 | 7.66 |
| CHEMBL138098 | — | — | 1 | 7.57 |
| CHEMBL141282 | — | — | 1 | 7.41 |
| CHEMBL137982 | — | — | 1 | 7.16 |
| CHEMBL336041 | — | — | 1 | 7.16 |
| CHEMBL141344 | — | — | 1 | 7.05 |
| CHEMBL140336 | — | — | 1 | 6.91 |
| CHEMBL138003 | — | — | 1 | 6.90 |
| CHEMBL137890 | — | — | 1 | 6.84 |
| CHEMBL138197 | — | — | 1 | 6.78 |
| CHEMBL141524 | — | — | 1 | 6.69 |
| CHEMBL343135 | — | — | 1 | 6.59 |
| CHEMBL141426 | — | — | 1 | 6.51 |
| CHEMBL138957 | — | — | 1 | - |
| CHEMBL138737 | — | — | 1 | - |
| CHEMBL141361 | — | — | 1 | - |
| CHEMBL138753 | — | — | 1 | - |
| CHEMBL140553 | — | — | 1 | - |
| CHEMBL342819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL97206 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL266282 | AL-43 | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL266282 | AL-43 | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL141836 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL337112 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL141915 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL138098 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL141282 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL137982 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL336041 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL141344 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL140336 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL138003 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL137890 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL138197 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL141524 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL343135 | — | EC50 | = | 255.0 | nM | 6.59 |
| CHEMBL141426 | — | EC50 | = | 306.0 | nM | 6.51 |
| CHEMBL266282 | AL-43 | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL138737 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL138957 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL141361 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL138753 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL140553 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL342819 | — | EC50 | > | 5000.0 | nM | - |