Assay Detail
Binding
CHEMBL658912
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Inhibition of recombinant human caspase-3
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective nonpeptide inhibitors of caspases 3 and 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.51 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439753 | — | — | 1 | 8.60 |
| CHEMBL60671 | — | — | 1 | 8.51 |
| CHEMBL300369 | — | — | 1 | 8.38 |
| CHEMBL64219 | — | — | 1 | 8.34 |
| CHEMBL64895 | — | — | 1 | 8.28 |
| CHEMBL1907830 | — | — | 1 | 7.51 |
| CHEMBL62993 | — | — | 1 | 7.36 |
| CHEMBL63493 | — | — | 1 | 7.36 |
| CHEMBL62282 | — | — | 1 | 7.16 |
| CHEMBL60190 | — | — | 1 | 6.92 |
| CHEMBL292058 | — | — | 1 | 6.77 |
| CHEMBL64789 | — | — | 1 | 6.77 |
| CHEMBL61815 | — | — | 1 | 6.77 |
| CHEMBL60306 | — | — | 1 | 6.60 |
| CHEMBL63044 | — | — | 1 | 6.39 |
| CHEMBL64584 | — | — | 1 | 6.22 |
| CHEMBL293460 | — | — | 1 | 6.04 |
| CHEMBL293622 | — | — | 1 | 6.00 |
| CHEMBL302461 | — | — | 1 | 5.72 |
| CHEMBL61320 | — | — | 1 | 5.66 |
| CHEMBL305545 | — | — | 1 | 5.55 |
| CHEMBL62187 | — | — | 1 | 5.26 |
| CHEMBL64413 | — | — | 1 | 5.16 |
| CHEMBL64582 | — | — | 1 | 4.82 |
| CHEMBL59905 | — | — | 1 | 4.75 |
| CHEMBL293034 | — | — | 2 | 4.52 |
| CHEMBL64730 | — | — | 1 | - |
| CHEMBL149556 | — | — | 1 | - |
| CHEMBL60569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439753 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL60671 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL300369 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL64219 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL64895 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1907830 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL63493 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL62993 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL62282 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL60190 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL61815 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL292058 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL64789 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL60306 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL63044 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL64584 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL293460 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL293622 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL302461 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL61320 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL305545 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL62187 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL64413 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL64582 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL59905 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL293034 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL293034 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL64730 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL149556 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL60569 | — | IC50 | > | 50000.0 | nM | - |