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Assay Detail

CHEMBL659206

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxic concentration against 50% survival of uninfected untreated control CEM-SS cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type CEM-SS
Confidence 1 — Organism
Curated By Intermediate

Target

CEM-SS (CHEMBL614548)
Type CELL-LINE
Organism Homo sapiens

Publication

Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Greco G, Novellino E, Altamura S, Di Renzo L.
J Med Chem (1996) 39 : 2672 -2680
PubMed 8709096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.87 5.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329653 1 5.31
CHEMBL328235 1 5.19
CHEMBL91318 1 5.16
CHEMBL92308 1 4.93
CHEMBL32718 1 4.74
CHEMBL91891 1 4.43
CHEMBL90115 1 4.34
CHEMBL91491 1 -
CHEMBL330479 1 -
CHEMBL313804 1 -
CHEMBL129 ZIDOVUDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329653 IC50 = 4900.0 nM 5.31
CHEMBL328235 IC50 = 6400.0 nM 5.19
CHEMBL91318 IC50 = 6900.0 nM 5.16
CHEMBL92308 IC50 = 11800.0 nM 4.93
CHEMBL32718 IC50 = 18300.0 nM 4.74
CHEMBL91891 IC50 = 37300.0 nM 4.43
CHEMBL90115 IC50 = 45200.0 nM 4.34
CHEMBL91491 IC50 > 150000.0 nM -
CHEMBL330479 IC50 = 120000.0 nM -
CHEMBL313804 IC50 = 100100.0 nM -
CHEMBL129 ZIDOVUDINE IC50 > 1000.0 nM -