Assay Detail
Binding
CHEMBL659499
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Compound was evaluated for the inhibitory activity against caspase-1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.59 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267338 | — | — | 1 | 9.96 |
| CHEMBL111965 | — | — | 1 | 9.43 |
| CHEMBL112207 | — | — | 1 | 9.40 |
| CHEMBL115952 | — | — | 1 | 8.77 |
| CHEMBL116124 | — | — | 1 | 8.72 |
| CHEMBL115336 | — | — | 1 | 8.70 |
| CHEMBL26719 | — | — | 1 | 8.00 |
| CHEMBL115823 | — | — | 1 | 7.89 |
| CHEMBL111938 | — | — | 1 | 7.73 |
| CHEMBL324470 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267338 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL111965 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL112207 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL115952 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL116124 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL115336 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL26719 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL115823 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL111938 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL324470 | — | IC50 | = | 46.0 | nM | 7.34 |