Compound Detail
CHEMBL115336
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CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N(CC(=O)NC(CC(=O)O)C(=O)c1nc2ccccc2o1)C1Cc2ccccc2C1
Basic Information
| ChEMBL ID | CHEMBL115336 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ICSUVLPLFSKXAO-WSXWNZDHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
610.7
MW (Da)
3.42
ALogP
7
HBA
3
HBD
158.9
PSA (Ų)
0.21
QED
1
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Caspase-1 CHEMBL4801 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Caspase-1 | IC50 | = | 2.0 | nM | 8.7 | Compound was evaluated for the inhibitory activity against caspase-1 | 10978183 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10978183 | 10.1021/jm000060f | Caspase-1 | 2 |
Data from ChEMBL 36 via Core Engine