Assay Detail
Binding
CHEMBL659607
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In vitro inhibitory activity against human coagulation factor X
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.68 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20438 | — | — | 1 | 9.00 |
| CHEMBL281838 | — | — | 1 | 8.70 |
| CHEMBL281141 | — | — | 1 | 8.70 |
| CHEMBL21250 | — | — | 1 | 8.70 |
| CHEMBL279486 | — | — | 1 | 8.52 |
| CHEMBL277657 | — | — | 1 | 8.40 |
| CHEMBL20918 | — | — | 1 | 8.30 |
| CHEMBL21179 | — | — | 1 | 8.22 |
| CHEMBL20932 | — | — | 1 | 8.15 |
| CHEMBL20496 | — | — | 1 | 8.15 |
| CHEMBL20390 | — | — | 1 | 8.15 |
| CHEMBL21562 | — | — | 1 | 8.10 |
| CHEMBL20897 | — | — | 1 | 8.10 |
| CHEMBL20391 | — | — | 1 | 8.10 |
| CHEMBL2092985 | — | — | 1 | 8.00 |
| CHEMBL282676 | — | — | 1 | 7.96 |
| CHEMBL20488 | — | — | 1 | 7.92 |
| CHEMBL280925 | — | — | 1 | 7.85 |
| CHEMBL418558 | — | — | 1 | 7.82 |
| CHEMBL281186 | — | — | 1 | 7.82 |
| CHEMBL417826 | — | — | 1 | 7.80 |
| CHEMBL277943 | — | — | 1 | 7.75 |
| CHEMBL21052 | — | — | 1 | 7.75 |
| CHEMBL21140 | — | — | 1 | 7.66 |
| CHEMBL21506 | — | — | 1 | 7.66 |
| CHEMBL282945 | — | — | 1 | 7.62 |
| CHEMBL281801 | — | — | 1 | 7.55 |
| CHEMBL431693 | — | — | 1 | 7.51 |
| CHEMBL21176 | — | — | 1 | 7.47 |
| CHEMBL418559 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20438 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL281838 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL21250 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL281141 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL279486 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL277657 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL20918 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL21179 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL20932 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20496 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20390 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20897 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL20391 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL21562 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2092985 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL282676 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL20488 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL280925 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL418558 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL281186 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL417826 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL277943 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL21052 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL21140 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL21506 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL282945 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL281801 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL431693 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL21176 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL418559 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL278141 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL428530 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL416181 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL280336 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL20567 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL20673 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL20420 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL282703 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL280214 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL279487 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL20651 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL20396 | — | IC50 | = | 777.0 | nM | 6.11 |