Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL659697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity was determined against rat brain Cannabinoid receptor 1
ChEMBL ↗
53
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cannabinoid receptor 1 (CHEMBL3571) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor.
Sheskin T, Hanus L, Slager J, Vogel Z, Mechoulam R.
J Med Chem (1997) 40 : 659 -667
PubMed 9057852 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 53 7.08 8.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160350 — — 1 8.16
CHEMBL423602 — — 1 8.14
CHEMBL158649 — — 1 8.13
CHEMBL160975 — — 1 8.08
CHEMBL429055 — — 1 7.93
CHEMBL16424 — — 1 7.87
CHEMBL423382 — — 1 7.59
CHEMBL277297 — — 1 7.52
CHEMBL2110161 — — 1 7.51
CHEMBL158468 — — 1 7.49
CHEMBL15873 — — 1 7.47
CHEMBL321585 — — 1 7.46
CHEMBL15848 ANANDAMIDE — 1 7.41
CHEMBL2110295 — — 1 7.33
CHEMBL121229 — — 1 7.27
CHEMBL15755 — — 1 7.22
CHEMBL75591 — — 1 7.07
CHEMBL150942 — — 1 6.86
CHEMBL2110160 — — 1 6.81
CHEMBL161521 — — 1 6.79
CHEMBL162244 — — 1 6.79
CHEMBL2110296 — — 1 6.72
CHEMBL158956 — — 1 6.72
CHEMBL15566 — — 1 6.63
CHEMBL359278 — — 1 6.62
CHEMBL161520 — — 1 6.49
CHEMBL151862 — — 1 6.42
CHEMBL159181 — — 1 6.35
CHEMBL160717 — — 1 6.30
CHEMBL158544 — — 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160350 — Ki = 6.9 nM 8.16
CHEMBL423602 — Ki = 7.2 nM 8.14
CHEMBL158649 — Ki = 7.4 nM 8.13
CHEMBL160975 — Ki = 8.4 nM 8.08
CHEMBL429055 — Ki = 11.7 nM 7.93
CHEMBL16424 — Ki = 13.6 nM 7.87
CHEMBL423382 — Ki = 25.5 nM 7.59
CHEMBL277297 — Ki = 29.9 nM 7.52
CHEMBL2110161 — Ki = 31.1 nM 7.51
CHEMBL158468 — Ki = 32.5 nM 7.49
CHEMBL15873 — Ki = 34.0 nM 7.47
CHEMBL321585 — Ki = 34.4 nM 7.46
CHEMBL15848 ANANDAMIDE Ki = 39.2 nM 7.41
CHEMBL2110295 — Ki = 46.6 nM 7.33
CHEMBL121229 — Ki = 53.4 nM 7.27
CHEMBL15755 — Ki = 60.0 nM 7.22
CHEMBL75591 — Ki = 85.2 nM 7.07
CHEMBL150942 — Ki = 138.6 nM 6.86
CHEMBL2110160 — Ki = 153.9 nM 6.81
CHEMBL162244 — Ki = 161.8 nM 6.79
CHEMBL161521 — Ki = 162.3 nM 6.79
CHEMBL158956 — Ki = 190.8 nM 6.72
CHEMBL2110296 — Ki = 191.4 nM 6.72
CHEMBL15566 — Ki = 235.7 nM 6.63
CHEMBL359278 — Ki = 239.9 nM 6.62
CHEMBL161520 — Ki = 324.1 nM 6.49
CHEMBL151862 — Ki = 377.2 nM 6.42
CHEMBL159181 — Ki = 446.7 nM 6.35
CHEMBL160717 — Ki = 497.4 nM 6.30
CHEMBL158544 — Ki = 575.1 nM 6.24
CHEMBL121316 — Ki = 1500.0 nM 5.82
CHEMBL149859 LINOLEOYLETHANOLAMIDE Ki = 4600.0 nM 5.34
CHEMBL160313 — Ki - nM -
CHEMBL15567 — Ki > 1000.0 nM -
CHEMBL15812 — Ki > 1000.0 nM -
CHEMBL158367 — Ki > 10000.0 nM -
CHEMBL277123 — Ki > 1000.0 nM -
CHEMBL161343 ARACHIDONOYL GLYCINE Ki > 10000.0 nM -
CHEMBL15948 — Ki > 10000.0 nM -
CHEMBL161596 — Ki > 10000.0 nM -
CHEMBL417675 PALMIDROL Ki - nM -
CHEMBL158880 — Ki > 1000.0 nM -
CHEMBL158277 — Ki > 1000.0 nM -
CHEMBL160351 — Ki - nM -
CHEMBL15150 ARACHIDONAMIDE Ki > 1000.0 nM -
CHEMBL160854 — Ki > 10000.0 nM -
CHEMBL160854 — Ki > 10000.0 nM -
CHEMBL149859 LINOLEOYLETHANOLAMIDE Ki > 25000.0 nM -
CHEMBL347615 — Ki > 1000.0 nM -
CHEMBL159221 — Ki > 10000.0 nM -