Compound Detail
CHEMBL417675
PALMIDROL 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL417675 |
| Name | PALMIDROL |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | HXYVTAGFYLMHSO-UHFFFAOYSA-N |
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
20
Publications
18
Known Names
7
Indications
Molecular Properties
299.5
MW (Da)
4.58
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.41
QED
0
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Migraine Disorders Bipolar Disorder Chronic Pain Mastocytosis Severe Acute Respiratory Syndrome Tourette Syndrome Opioid-Related Disorders
Activity Summary
IC50 7 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.3 | 5.6 | 501.2 | 3 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 5.3 | 5.3 | 5011.9 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 5.3 | 5.09 | 5011.9 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 501.19 | nM | 6.3 | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR g... | 19734910 |
| Plasmodium falciparum | IC50 | = | 3162.28 | nM | 5.5 | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR gr... | 19734910 |
| Rattus norvegicus | IC50 | = | 5011.87 | nM | 5.3 | Inhibition of [3H]- AEA metabolism (N-arachidonoylethanolamine) in rat brain hom... | 12672243 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 5011.87 | nM | 5.3 | Inhibition of rat recombinant FAAH assessed as [3H]AEA hydrolysis | 19054678 |
| Rattus norvegicus | IC50 | = | 9120.11 | nM | 5.04 | Inhibition of [3H]- AEA metabolism (N-arachidonoylethanolamine) using rat brain ... | 12672243 |
| Plasmodium falciparum | IC50 | = | 10000.0 | nM | 5.0 | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR g... | 19734910 |
| Rattus norvegicus | IC50 | = | 11748.98 | nM | 4.93 | Inhibition of [3H]- AEA metabolism (N-arachidonoylethanolamine) using rat brain ... | 12672243 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-010-9357-7 | Mus musculus | 12 |
| 12672243 | 10.1021/jm0209679 | Rattus norvegicus | 6 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 6 |
| 19734910 | 10.1038/nchembio.215 | Plasmodium falciparum | 3 |
| 20667727 | 10.1016/j.bmcl.2010.06.149 | Mycobacterium tuberculosis | 3 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 21257314 | 10.1016/j.bmc.2010.12.046 | HaCaT | 2 |
| 25510639 | 10.1016/j.bmc.2014.11.019 | NON-PROTEIN TARGET | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 16570929 | 10.1021/jm051240y | Transient receptor potential cation channel subfamily V member 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| 23384387 | 10.1021/jm300484d | Transient receptor potential cation channel subfamily V member 1 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 14521402 | 10.1021/jm0340795 | Fatty-acid amide hydrolase 1 | 2 |
| 25510639 | 10.1016/j.bmc.2014.11.019 | NCI/ADR-RES | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 9057852 | 10.1021/jm960752x | Cannabinoid receptor 1 | 2 |
| 30176215 | 10.1021/acs.jmedchem.8b00734 | Transient receptor potential cation channel subfamily V member 2 | 2 |
Data from ChEMBL 36 via Core Engine