Assay Detail
Functional
CHEMBL798359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- AEA metabolism (N-arachidonoylethanolamine) using rat brain homogenates at pH 9 using [3H]anandamide as the labeled substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.94 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32174 | N-(3-HYDROXYPROPYL)PALMITAMIDE | — | 1 | 5.16 |
| CHEMBL417675 | PALMIDROL | 3.0 | 1 | 5.04 |
| CHEMBL32827 | HEXADECANOIC ACID ISOPROPYLAMIDE | — | 1 | 4.85 |
| CHEMBL286321 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32174 | N-(3-HYDROXYPROPYL)PALMITAMIDE | IC50 | = | 6918.31 | nM | 5.16 |
| CHEMBL417675 | PALMIDROL | IC50 | = | 9120.11 | nM | 5.04 |
| CHEMBL32827 | HEXADECANOIC ACID ISOPROPYLAMIDE | IC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL286321 | — | IC50 | = | 19054.61 | nM | 4.72 |