Assay Detail
Functional
CHEMBL803322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- AEA metabolism (N-arachidonoylethanolamine) in rat brain homogenates using [3H]anandamide as the labeled substrate.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.05 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32433 | — | — | 1 | 5.60 |
| CHEMBL33355 | — | — | 1 | 5.58 |
| CHEMBL35286 | HEXADECANOIC ACID PROPYLAMIDE | — | 1 | 5.56 |
| CHEMBL32319 | HEXADECANOIC ACID BUTYLAMIDE | — | 1 | 5.54 |
| CHEMBL32650 | HEXADECANOIC ACID ALLYLAMIDE | — | 1 | 5.47 |
| CHEMBL32886 | N-ETHYLPALMITAMIDE | — | 1 | 5.45 |
| CHEMBL33716 | — | — | 1 | 5.45 |
| CHEMBL32174 | N-(3-HYDROXYPROPYL)PALMITAMIDE | — | 1 | 5.42 |
| CHEMBL34404 | HEXADECANOIC ACID CYCLOPROPYLAMIDE | — | 1 | 5.35 |
| CHEMBL289007 | HEXADECANOIC ACID PHENYLAMIDE | — | 1 | 5.31 |
| CHEMBL417675 | PALMIDROL | 3.0 | 1 | 5.30 |
| CHEMBL34112 | ACETIC ACID PENTADECYLCARBAMOYLMETHYL ESTER | — | 1 | 5.08 |
| CHEMBL32605 | PALMITAMIDE | — | 1 | 5.01 |
| CHEMBL286321 | — | — | 1 | 4.99 |
| CHEMBL32827 | HEXADECANOIC ACID ISOPROPYLAMIDE | — | 1 | 4.89 |
| CHEMBL441423 | — | — | 1 | 4.85 |
| CHEMBL422938 | — | — | 1 | 4.70 |
| CHEMBL36285 | HEXADECANOIC ACID METHYLAMIDE | — | 1 | 4.57 |
| CHEMBL33245 | — | — | 1 | 4.40 |
| CHEMBL33143 | — | — | 1 | 4.27 |
| CHEMBL34340 | — | — | 1 | 4.15 |
| CHEMBL32504 | — | — | 1 | 4.07 |
| CHEMBL32472 | — | — | 1 | - |
| CHEMBL34047 | HEXADECANOIC ACID DIMETHYLAMIDE | — | 1 | - |
| CHEMBL284042 | HEXADECANOIC ACID CYCLOPENTYLAMIDE | — | 1 | - |
| CHEMBL33707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32433 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL33355 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL35286 | HEXADECANOIC ACID PROPYLAMIDE | IC50 | = | 2754.23 | nM | 5.56 |
| CHEMBL32319 | HEXADECANOIC ACID BUTYLAMIDE | IC50 | = | 2884.03 | nM | 5.54 |
| CHEMBL32650 | HEXADECANOIC ACID ALLYLAMIDE | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL32886 | N-ETHYLPALMITAMIDE | IC50 | = | 3548.13 | nM | 5.45 |
| CHEMBL33716 | — | IC50 | = | 3548.13 | nM | 5.45 |
| CHEMBL32174 | N-(3-HYDROXYPROPYL)PALMITAMIDE | IC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL34404 | HEXADECANOIC ACID CYCLOPROPYLAMIDE | IC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL289007 | HEXADECANOIC ACID PHENYLAMIDE | IC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL417675 | PALMIDROL | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL34112 | ACETIC ACID PENTADECYLCARBAMOYLMETHYL ESTER | IC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL32605 | PALMITAMIDE | IC50 | = | 9772.37 | nM | 5.01 |
| CHEMBL286321 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL32827 | HEXADECANOIC ACID ISOPROPYLAMIDE | IC50 | = | 12882.5 | nM | 4.89 |
| CHEMBL441423 | — | IC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL422938 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL36285 | HEXADECANOIC ACID METHYLAMIDE | IC50 | = | 26915.35 | nM | 4.57 |
| CHEMBL33245 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL33143 | — | IC50 | = | 53703.18 | nM | 4.27 |
| CHEMBL34340 | — | IC50 | = | 70794.58 | nM | 4.15 |
| CHEMBL32504 | — | IC50 | = | 85113.8 | nM | 4.07 |
| CHEMBL32472 | — | IC50 | = | 199526.23 | nM | - |
| CHEMBL34047 | HEXADECANOIC ACID DIMETHYLAMIDE | IC50 | = | 251188.64 | nM | - |
| CHEMBL284042 | HEXADECANOIC ACID CYCLOPENTYLAMIDE | IC50 | = | 158489.32 | nM | - |
| CHEMBL33707 | — | IC50 | = | 125892.54 | nM | - |