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Assay Detail

CHEMBL659910

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ligand binding to Cholecystokinin type A receptor from rat pancreatic tissue.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL2871)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.
Castro JL, Broughton HB, Russell MG, Rathbone D, Watt AP, Ball RG, Chapman KL, Patel S, Smith AJ, Marshall GR, Matassa VG.
J Med Chem (1997) 40 : 2491 -2501
PubMed 9258356 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.96 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL311061 1 8.00
CHEMBL82685 1 7.19
CHEMBL313813 1 6.36
CHEMBL315214 1 6.32
CHEMBL9387 L-365260 1 6.13
CHEMBL419663 1 5.86
CHEMBL84433 1 5.82
CHEMBL420783 L-740093 1 5.80
CHEMBL314846 1 5.76
CHEMBL58699 1 5.75
CHEMBL311638 1 5.68
CHEMBL313653 1 5.52
CHEMBL309299 1 5.52
CHEMBL313983 1 5.51
CHEMBL83591 1 5.45
CHEMBL79565 1 5.40
CHEMBL83130 1 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL311061 IC50 = 10.0 nM 8.00
CHEMBL82685 IC50 = 65.0 nM 7.19
CHEMBL313813 IC50 = 435.0 nM 6.36
CHEMBL315214 IC50 = 480.0 nM 6.32
CHEMBL9387 L-365260 IC50 = 736.0 nM 6.13
CHEMBL419663 IC50 = 1390.0 nM 5.86
CHEMBL84433 IC50 = 1510.0 nM 5.82
CHEMBL420783 L-740093 IC50 = 1600.0 nM 5.80
CHEMBL314846 IC50 = 1750.0 nM 5.76
CHEMBL58699 IC50 = 1800.0 nM 5.75
CHEMBL311638 IC50 = 2090.0 nM 5.68
CHEMBL313653 IC50 = 3000.0 nM 5.52
CHEMBL309299 IC50 = 3000.0 nM 5.52
CHEMBL313983 IC50 = 3090.0 nM 5.51
CHEMBL83591 IC50 = 3540.0 nM 5.45
CHEMBL79565 IC50 = 4020.0 nM 5.40
CHEMBL83130 IC50 = 6490.0 nM 5.19