Assay Detail
ADMET
CHEMBL660403
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Inhibition of human cytochrome P450 2C9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.73 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96347 | — | — | 1 | 4.82 |
| CHEMBL330354 | — | — | 1 | 4.82 |
| CHEMBL319754 | — | — | 1 | 4.55 |
| CHEMBL330425 | — | — | 1 | - |
| CHEMBL329477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96347 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL330354 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL319754 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL330425 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL329477 | — | IC50 | > | 50000.0 | nM | - |