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Assay Detail

CHEMBL660847

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Binding
Inhibition of Coagulation factor Xa
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.
He W, Hanney B, Myers MR, Condon S, Becker MR, Spada AP, Burns C, Brown K, Colussi D, Chu V.
Bioorg Med Chem Lett (2002) 12 : 919 -922
PubMed 11958994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.35 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL173650 1 9.00
CHEMBL48813 1 9.00
CHEMBL366731 1 8.52
CHEMBL354996 1 8.00
CHEMBL48236 1 7.92
CHEMBL173333 1 7.77
CHEMBL172928 1 7.62
CHEMBL367731 1 7.40
CHEMBL354154 1 6.92
CHEMBL174409 1 6.54
CHEMBL367072 1 6.41
CHEMBL173210 1 5.92
CHEMBL174138 1 5.92
CHEMBL170093 1 5.92
CHEMBL368385 1 -
CHEMBL352973 1 -
CHEMBL354351 1 -
CHEMBL170570 1 -
CHEMBL171249 1 -
CHEMBL367861 1 -
CHEMBL174370 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL173650 Ki = 1.0 nM 9.00
CHEMBL48813 Ki = 1.0 nM 9.00
CHEMBL366731 Ki = 3.0 nM 8.52
CHEMBL354996 Ki = 10.0 nM 8.00
CHEMBL48236 Ki = 12.0 nM 7.92
CHEMBL173333 Ki = 17.0 nM 7.77
CHEMBL172928 Ki = 24.0 nM 7.62
CHEMBL367731 Ki = 40.0 nM 7.40
CHEMBL354154 Ki = 120.0 nM 6.92
CHEMBL174409 Ki = 290.0 nM 6.54
CHEMBL367072 Ki = 390.0 nM 6.41
CHEMBL173210 Ki = 1200.0 nM 5.92
CHEMBL174138 Ki = 1200.0 nM 5.92
CHEMBL170093 Ki = 1200.0 nM 5.92
CHEMBL368385 Ki >> 1200.0 nM -
CHEMBL352973 Ki > 1200.0 nM -
CHEMBL354351 Ki >> 1200.0 nM -
CHEMBL170570 Ki >> 1200.0 nM -
CHEMBL171249 Ki >> 1200.0 nM -
CHEMBL367861 Ki >> 1200.0 nM -
CHEMBL174370 Ki >> 1200.0 nM -