Assay Detail

CHEMBL661230

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ADMET

Inhibition of human cytochrome P450 2C9

ChEMBL ↗

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Target

Cytochrome P450 2C9 (CHEMBL3397) ↗

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Cytochrome P450 2C9 (CHEMBL3397) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2C9

CHEMBL3397

Anchored from Assay target.

Protein identity Cytochrome P450 2C9

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Cytochrome P450 2C9 (CHEMBL3397) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.

Afzelius L, Zamora I, Masimirembwa CM, Karlén A, Andersson TB, Mecucci S, Baroni M, Cruciani G.
J Med Chem (2004) 47 : 907 -914
PubMed 14761192 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.55	6.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1484	NICARDIPINE	4.0	1	6.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1484	NICARDIPINE	Ki	=	280.0	nM	6.55