Assay Detail
Binding
CHEMBL661838
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Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 7.31 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9203 | — | — | 1 | 9.00 |
| CHEMBL9405 | — | — | 1 | 8.92 |
| CHEMBL9188 | — | — | 1 | 8.82 |
| CHEMBL8890 | — | — | 1 | 8.72 |
| CHEMBL266557 | — | — | 1 | 8.62 |
| CHEMBL9406 | — | — | 1 | 8.30 |
| CHEMBL9267 | — | — | 1 | 8.30 |
| CHEMBL275307 | — | — | 1 | 8.24 |
| CHEMBL276627 | — | — | 1 | 8.23 |
| CHEMBL8954 | — | — | 1 | 8.10 |
| CHEMBL9449 | — | — | 1 | 8.10 |
| CHEMBL9534 | — | — | 1 | 8.10 |
| CHEMBL9387 | L-365260 | — | 1 | 8.07 |
| CHEMBL9026 | — | — | 1 | 8.03 |
| CHEMBL9319 | — | — | 1 | 8.00 |
| CHEMBL266120 | — | — | 1 | 7.96 |
| CHEMBL8997 | — | — | 1 | 7.85 |
| CHEMBL9083 | — | — | 1 | 7.85 |
| CHEMBL9524 | — | — | 1 | 7.85 |
| CHEMBL9422 | — | — | 1 | 7.85 |
| CHEMBL9291 | — | — | 1 | 7.82 |
| CHEMBL9354 | — | — | 1 | 7.82 |
| CHEMBL9459 | — | — | 1 | 7.80 |
| CHEMBL8922 | — | — | 1 | 7.66 |
| CHEMBL9195 | — | — | 1 | 7.64 |
| CHEMBL9311 | — | — | 1 | 7.60 |
| CHEMBL9501 | — | — | 1 | 7.58 |
| CHEMBL267023 | — | — | 1 | 7.54 |
| CHEMBL269123 | — | — | 1 | 7.48 |
| CHEMBL415965 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9203 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL9405 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL9188 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL8890 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL266557 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL9406 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL9267 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL275307 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL276627 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL8954 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL9449 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL9534 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL9387 | L-365260 | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL9026 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL9319 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL266120 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL8997 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL9083 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL9524 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL9422 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL9291 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL9354 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL9459 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL8922 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL9195 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL9311 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL9501 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL267023 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL269123 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL415965 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL9377 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL262569 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL269662 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL9171 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL9287 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL9888 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL9535 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL269606 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL273693 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL9336 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL266376 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9465 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL269142 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL9492 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL8921 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL8920 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL266598 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL9230 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL266523 | — | IC50 | = | 915.0 | nM | 6.04 |
| CHEMBL8905 | — | IC50 | = | 1083.0 | nM | 5.96 |