Assay Detail
Binding
CHEMBL661895
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Binding affinity against human Cathepsin G
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.35 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130656 | — | — | 1 | 5.96 |
| CHEMBL130190 | — | — | 1 | 5.52 |
| CHEMBL130006 | — | — | 1 | 5.16 |
| CHEMBL132171 | — | — | 1 | 4.77 |
| CHEMBL130128 | — | — | 1 | - |
| CHEMBL339870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130656 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL130190 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL130006 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL132171 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL130128 | — | Ki | > | 800000.0 | nM | - |
| CHEMBL339870 | — | Ki | > | 600000.0 | nM | - |