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Compound Detail

CHEMBL132171

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COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)C(F)(F)F

Basic Information

ChEMBL ID CHEMBL132171
Phase Preclinical
Structure Type MOL
InChI Key RGSIFPCCTSSAKZ-CAMMJAKZSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

570.6
MW (Da)
0.80
ALogP
7
HBA
3
HBD
151.0
PSA (Ų)
0.31
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H33F3N4O7
MW 570.57
Aromatic Rings 1
Heavy Atoms 40
NP-Likeness -0.60

Activity Summary

Ki 3 meas. best 7.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Chymotrypsinogen B
CHEMBL4796
Ki 7.77 7.77 17.0 1
Cathepsin G
CHEMBL4071
Ki 5.8 5.285 1600.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2296031 10.1021/jm00163a063 Cathepsin G 2
2296031 10.1021/jm00163a063 Chymotrypsin-like elastase family member 1 1
2296031 10.1021/jm00163a063 Chymotrypsinogen B 1

Data from ChEMBL 36 via Core Engine