Assay Detail
Binding
CHEMBL662233
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Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.41 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 10.10 |
| CHEMBL420320 | — | — | 1 | 8.55 |
| CHEMBL70380 | — | — | 1 | 8.52 |
| CHEMBL419764 | — | — | 1 | 8.08 |
| CHEMBL138534 | — | — | 1 | 7.59 |
| CHEMBL9387 | L-365260 | — | 1 | 6.55 |
| CHEMBL117281 | — | — | 1 | 5.19 |
| CHEMBL333081 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL420320 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL70380 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL419764 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL138534 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL9387 | L-365260 | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL117281 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL333081 | — | IC50 | = | 20500.0 | nM | 4.69 |