Assay Detail
Binding
CHEMBL662394
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In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type A receptor from rat pancreatic tissues was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
L-708,474: The C5-cyclohexyl analogue of L-365,260, a selective high affinity ligand for the CCKB/gastrin receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.04 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410035 | — | — | 1 | 9.34 |
| CHEMBL56944 | — | — | 1 | 7.57 |
| CHEMBL293786 | — | — | 1 | 6.40 |
| CHEMBL9387 | L-365260 | — | 1 | 6.13 |
| CHEMBL58699 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410035 | — | IC50 | = | 0.455 | nM | 9.34 |
| CHEMBL56944 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL293786 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL9387 | L-365260 | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL58699 | — | IC50 | = | 1797.0 | nM | 5.75 |