Assay Detail
Binding
CHEMBL662403
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Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreas
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.52 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 10.10 |
| CHEMBL1907852 | — | — | 1 | 9.41 |
| CHEMBL2092868 | — | — | 1 | 8.54 |
| CHEMBL70380 | — | — | 1 | 8.52 |
| CHEMBL289498 | — | — | 1 | 8.09 |
| CHEMBL355092 | — | — | 1 | 7.58 |
| CHEMBL41361 | — | — | 1 | 7.29 |
| CHEMBL40668 | — | — | 1 | 6.96 |
| CHEMBL289533 | — | — | 1 | 6.96 |
| CHEMBL417521 | — | — | 1 | 6.66 |
| CHEMBL9387 | L-365260 | — | 1 | 6.55 |
| CHEMBL38404 | — | — | 1 | 6.43 |
| CHEMBL445095 | — | — | 1 | 6.28 |
| CHEMBL169661 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1907852 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL2092868 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL70380 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL289498 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL355092 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL41361 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL40668 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL289533 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL417521 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL9387 | L-365260 | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL38404 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL445095 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL169661 | — | IC50 | = | 1100.0 | nM | 5.96 |