Assay Detail
Binding
CHEMBL662406
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Binding affinity towards Cholecystokinin type A receptor (CCK-A) receptor from rat pancreas using [125I]bolton Hunter CCK-8 as radioligand
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.52 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9465 | — | — | 1 | 6.97 |
| CHEMBL9534 | — | — | 1 | 6.85 |
| CHEMBL9387 | L-365260 | — | 1 | 6.13 |
| CHEMBL9195 | — | — | 1 | 6.03 |
| CHEMBL273693 | — | — | 1 | 6.01 |
| CHEMBL9267 | — | — | 1 | 5.92 |
| CHEMBL9449 | — | — | 1 | 5.92 |
| CHEMBL266598 | — | — | 1 | 5.79 |
| CHEMBL262569 | — | — | 1 | 5.78 |
| CHEMBL8954 | — | — | 1 | 5.65 |
| CHEMBL9354 | — | — | 1 | 5.63 |
| CHEMBL276627 | — | — | 1 | 5.62 |
| CHEMBL9377 | — | — | 1 | 5.59 |
| CHEMBL9203 | — | — | 1 | 5.59 |
| CHEMBL9406 | — | — | 1 | 5.58 |
| CHEMBL415965 | — | — | 1 | 5.56 |
| CHEMBL8890 | — | — | 1 | 5.53 |
| CHEMBL9287 | — | — | 1 | 5.52 |
| CHEMBL269662 | — | — | 1 | 5.50 |
| CHEMBL9188 | — | — | 1 | 5.46 |
| CHEMBL9422 | — | — | 1 | 5.46 |
| CHEMBL8997 | — | — | 1 | 5.45 |
| CHEMBL9319 | — | — | 1 | 5.38 |
| CHEMBL275307 | — | — | 1 | 5.35 |
| CHEMBL9291 | — | — | 1 | 5.34 |
| CHEMBL9171 | — | — | 1 | 5.31 |
| CHEMBL269123 | — | — | 1 | 5.30 |
| CHEMBL266376 | — | — | 1 | 5.29 |
| CHEMBL9405 | — | — | 1 | 5.27 |
| CHEMBL9888 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9465 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL9534 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL9387 | L-365260 | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL9195 | — | IC50 | = | 925.0 | nM | 6.03 |
| CHEMBL273693 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL9267 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL9449 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL266598 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL262569 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL8954 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL9354 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL276627 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL9377 | — | IC50 | = | 2568.0 | nM | 5.59 |
| CHEMBL9203 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL9406 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL415965 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL8890 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL9287 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL269662 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL9422 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL9188 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL8997 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL9319 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL275307 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL9291 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL9171 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL269123 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL266376 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL9405 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL9888 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL266120 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL9083 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2051984 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL8922 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL267023 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL8921 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL266819 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL9311 | — | IC50 | = | 15490.0 | nM | 4.81 |
| CHEMBL269606 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL264087 | — | IC50 | > | 1000.0 | nM | - |