Assay Detail
Binding
CHEMBL662415
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Inhibition of [125I]Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type A receptor of rat pancreatic membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dual CCK-A and -B receptor antagonists (I) C9-methyl-1,4-benzodiazepines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.09 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 10.10 |
| CHEMBL300072 | PRANAZEPIDE | 2.0 | 1 | 9.17 |
| CHEMBL299523 | — | — | 1 | 8.29 |
| CHEMBL50216 | — | — | 1 | 8.14 |
| CHEMBL48563 | — | — | 1 | 8.13 |
| CHEMBL50215 | — | — | 1 | 7.89 |
| CHEMBL285921 | — | — | 1 | 7.85 |
| CHEMBL299800 | — | — | 1 | 7.77 |
| CHEMBL413267 | — | — | 1 | 7.68 |
| CHEMBL49085 | — | — | 1 | 7.21 |
| CHEMBL50926 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL300072 | PRANAZEPIDE | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL299523 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL50216 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL48563 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL50215 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL285921 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL299800 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL413267 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL49085 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL50926 | — | IC50 | = | 160.0 | nM | 6.80 |